One of the most exciting topics about NAD is how it might affect athletic performance. We already know that NAD+ works to quickly repair cells throughout body and neurons in the brain. We also know that it is an essential coenzyme and found throughout every cell of the body. NAD+ is responsible for thousands of biochemical reactions throughout the body and is especially involved in DNA repair and energy production within the mitochondria of each cell.
NAD+ helps convert nutrition into energy by transferring electrons during cellular metabolism. Our bodies need a constant supply of NAD+ in order to facilitate repair of damaged DNA. This is especially true for mitochondrial DNA.
Some animal studies have shown that boosting NAD+ levels and availability may protect skeletal muscle from age-related metabolic decline.
Fatigue can be defined as a decrease in skeletal muscle contraction ability due to intense muscle activity. Fatigue is associated with several physiological factors including reduced neural input and disruptive metabolic changes in skeletal muscle such as overproduction of oxidative free radicals and lactic acidosis.
Studies show that before one reaches exhaustion, NADH levels rise while levels of NAD+ decrease in blood and muscle. An increase in NADH levels in the presence of decreased ATP (as occurs in fatigue) suggests the transfer of electrons from NADH may be compromised, thus impeding muscle performance resulting in fatigue.
Increased levels of NADH in the presence of decreased ATP that occurs in fatigue may be due to a compromise in electron transfer from NADH which in turn impairs muscle performance.
Fatigue and exhaustion increase oxidative stress and free radicals during exercise.
The study concluded that supplementation that increase blood and muscle levels of NAD+ may enhance endurance by reducing oxidative stress-induced suppression of aerobic respiration.
Here in our clinic we deliver NAD+ intravenously and directly into the bloodstream to elevate levels quickly. This may help athletes with overall endurance and performance.
Mach, J. et al. The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD+(H). Nutrients. 2010 Mar; 2(3): 319–329.