IV NAD+ and Depression

Major depression is one the most common mental disorders in the United States with an estimated 16 million adults and 3.1 million adolescents suffering at least one major depressive episode.


Feeling sad, or empty

Anger, irritability, frustration

Loss of interest, pleasure in normal activities (hobbies, sports, sex)

Sleep disturbances (insomnia, hypersomnia)

Lack of energy

Reduced appetite, weight loss or weight gain

Slower cognition, body motion

Feelings of guilt, worthlessness

Difficulty concentrating

Thoughts of death or suicide

Physical ailments

Loss of work


There are 3 parts of the brain that play a role in major depressive disorder: the amygdala, the prefrontal cortex and the hippocampus.The hippocampus is located in the middle of the brain and is responsible for regulating the stress hormone cortisol.Excessive cortisol can be secreted in response to episodes of depression. Excessive cortisol can impede the new formation of neurons and shrink the prefrontal cortex and hippocampus. This can lead to memory loss, emotional disturbances and cognitive dysfunction. The amygdala on the other hand enlarges under stressful situations and increased cortisol. This can result in sleep and activity disturbances.


IV NAD+ therapy regulates Sirtuin proteins which decreases inflammation and dysregulation in cells. IV NAD+ helps repair neuronal DNA and increases energy within each cell. Decreased levels of Sirtuins have been found in people with mood disorders. IV NAD+ increases levels of Sirtuins and thus have a protective role in neuronal activity.


Sirtuins are associated with:


Growth of new neurons

Decreased inflammation in microglial cells (they remove damaged neurons and infections and are important for maintaining the health of the central nervous system)

Protecting neurons against damage

Increased enzymes that decrease anxiety and depression

Protecting neurons from oxidative stress

Reparation of Mitochondrial DNA


Therefore, IV NAD+ therapy can increase levels of Sirtuins and thus help relieve people of depressive symptoms by revitalizing cellular function.


Please contact us today here at Upstate IV Therapy at 518-720-7674 for more information and to book a treatment program.

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